Protective Immunity Based on the Conserved Hemagglutinin Stalk Domain and Its Prospects for Universal Influenza Vaccine Development
Identifieur interne : 000686 ( Main/Exploration ); précédent : 000685; suivant : 000687Protective Immunity Based on the Conserved Hemagglutinin Stalk Domain and Its Prospects for Universal Influenza Vaccine Development
Auteurs : Madhu Khanna [Inde] ; Sachin Sharma [Inde] ; Binod Kumar [Inde] ; Roopali Rajput [Inde]Source :
- BioMed Research International [ 2314-6133 ] ; 2014.
Abstract
Influenza virus surface glycoprotein hemagglutinin (HA) is an excellent and chief target that
Url:
DOI: 10.1155/2014/546274
PubMed: 24982895
PubMed Central: 4055638
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000923
- to stream Pmc, to step Curation: 000923
- to stream Pmc, to step Checkpoint: 000473
- to stream Ncbi, to step Merge: 000A62
- to stream Ncbi, to step Curation: 000A62
- to stream Ncbi, to step Checkpoint: 000A62
- to stream Main, to step Merge: 000687
- to stream Main, to step Curation: 000686
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Protective Immunity Based on the Conserved Hemagglutinin Stalk Domain and Its Prospects for Universal Influenza Vaccine Development</title><author><name sortKey="Khanna, Madhu" sort="Khanna, Madhu" uniqKey="Khanna M" first="Madhu" last="Khanna">Madhu Khanna</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Respiratory Virology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110007, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Respiratory Virology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110007</wicri:regionArea><wicri:noRegion>Delhi 110007</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Sachin" sort="Sharma, Sachin" uniqKey="Sharma S" first="Sachin" last="Sharma">Sachin Sharma</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Respiratory Virology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110007, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Respiratory Virology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110007</wicri:regionArea><wicri:noRegion>Delhi 110007</wicri:noRegion></affiliation></author><author><name sortKey="Kumar, Binod" sort="Kumar, Binod" uniqKey="Kumar B" first="Binod" last="Kumar">Binod Kumar</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Respiratory Virology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110007, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Respiratory Virology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110007</wicri:regionArea><wicri:noRegion>Delhi 110007</wicri:noRegion></affiliation></author><author><name sortKey="Rajput, Roopali" sort="Rajput, Roopali" uniqKey="Rajput R" first="Roopali" last="Rajput">Roopali Rajput</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Respiratory Virology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110007, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Respiratory Virology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110007</wicri:regionArea><wicri:noRegion>Delhi 110007</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24982895</idno><idno type="pmc">4055638</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055638</idno><idno type="RBID">PMC:4055638</idno><idno type="doi">10.1155/2014/546274</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000923</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000923</idno><idno type="wicri:Area/Pmc/Curation">000923</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000923</idno><idno type="wicri:Area/Pmc/Checkpoint">000473</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000473</idno><idno type="wicri:Area/Ncbi/Merge">000A62</idno><idno type="wicri:Area/Ncbi/Curation">000A62</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A62</idno><idno type="wicri:doubleKey">2314-6133:2014:Khanna M:protective:immunity:based</idno><idno type="wicri:Area/Main/Merge">000687</idno><idno type="wicri:Area/Main/Curation">000686</idno><idno type="wicri:Area/Main/Exploration">000686</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Protective Immunity Based on the Conserved Hemagglutinin Stalk Domain and Its Prospects for Universal Influenza Vaccine Development</title><author><name sortKey="Khanna, Madhu" sort="Khanna, Madhu" uniqKey="Khanna M" first="Madhu" last="Khanna">Madhu Khanna</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Respiratory Virology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110007, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Respiratory Virology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110007</wicri:regionArea><wicri:noRegion>Delhi 110007</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Sachin" sort="Sharma, Sachin" uniqKey="Sharma S" first="Sachin" last="Sharma">Sachin Sharma</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Respiratory Virology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110007, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Respiratory Virology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110007</wicri:regionArea><wicri:noRegion>Delhi 110007</wicri:noRegion></affiliation></author><author><name sortKey="Kumar, Binod" sort="Kumar, Binod" uniqKey="Kumar B" first="Binod" last="Kumar">Binod Kumar</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Respiratory Virology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110007, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Respiratory Virology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110007</wicri:regionArea><wicri:noRegion>Delhi 110007</wicri:noRegion></affiliation></author><author><name sortKey="Rajput, Roopali" sort="Rajput, Roopali" uniqKey="Rajput R" first="Roopali" last="Rajput">Roopali Rajput</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Respiratory Virology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110007, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Respiratory Virology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110007</wicri:regionArea><wicri:noRegion>Delhi 110007</wicri:noRegion></affiliation></author></analytic><series><title level="j">BioMed Research International</title><idno type="ISSN">2314-6133</idno><idno type="eISSN">2314-6141</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Influenza virus surface glycoprotein hemagglutinin (HA) is an excellent and chief target that <italic>elicits</italic> neutralizing antibodies during vaccination or natural infection. Its HA2 subunit (stem domain) is most conserved as compared to HA1 subunit (globular head domain). Current influenza vaccine relies on globular head domain that provides protection only against the homologous vaccine strains, rarely provides cross-protection against divergent strains, and needs to be updated annually. There is an urge for a truly universal vaccine that provides broad cross-protection against different subtype influenza A viruses along with influenza B viruses and need not be updated annually. Antibodies against the stem domain of hemagglutinin (HA) are able to neutralize a wide spectrum of influenza virus strains and subtypes. These stem-specific antibodies have great potential for the development of universal vaccine against influenza viruses. In this review, we have discussed the stem-specific cross-reactive antibodies and heterosubtypic protection provided by them. We have also discussed their epitope-based DNA vaccine and their future prospects in this scenario.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Tong, S" uniqKey="Tong S">S Tong</name></author><author><name sortKey="Zhu, X" uniqKey="Zhu X">X Zhu</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Shi, M" uniqKey="Shi M">M Shi</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Bourgeois, M" uniqKey="Bourgeois M">M Bourgeois</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, X" uniqKey="Zhu X">X Zhu</name></author><author><name sortKey="Yu, W" uniqKey="Yu W">W Yu</name></author><author><name sortKey="Mcbride, R" uniqKey="Mcbride R">R McBride</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name></author><author><name sortKey="Morens, Dm" uniqKey="Morens D">DM Morens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Vijaykrishna, D" uniqKey="Vijaykrishna D">D Vijaykrishna</name></author><author><name sortKey="Bahl, J" uniqKey="Bahl J">J Bahl</name></author><author><name sortKey="Zhu, H" uniqKey="Zhu H">H Zhu</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name></author><author><name sortKey="Smith, Gjd" uniqKey="Smith G">GJD Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khanna, M" uniqKey="Khanna M">M Khanna</name></author><author><name sortKey="Saxena, L" uniqKey="Saxena L">L Saxena</name></author><author><name sortKey="Gupta, A" uniqKey="Gupta A">A Gupta</name></author><author><name sortKey="Kumar, B" uniqKey="Kumar B">B Kumar</name></author><author><name sortKey="Rajput, R" uniqKey="Rajput R">R Rajput</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goldsmith, C" uniqKey="Goldsmith C">C Goldsmith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ekiert, Dc" uniqKey="Ekiert D">DC Ekiert</name></author><author><name sortKey="Bhabha, G" uniqKey="Bhabha G">G Bhabha</name></author><author><name sortKey="Elsliger, M A" uniqKey="Elsliger M">M-A Elsliger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Belser, Ja" uniqKey="Belser J">JA Belser</name></author><author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name></author><author><name sortKey="Maines, Tr" uniqKey="Maines T">TR Maines</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, Yp" uniqKey="Lin Y">YP Lin</name></author><author><name sortKey="Shaw, M" uniqKey="Shaw M">M Shaw</name></author><author><name sortKey="Gregory, V" uniqKey="Gregory V">V Gregory</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Claas, Ecj" uniqKey="Claas E">ECJ Claas</name></author><author><name sortKey="Osterhaus, Adme" uniqKey="Osterhaus A">ADME Osterhaus</name></author><author><name sortKey="Van Beek, R" uniqKey="Van Beek R">R Van Beek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beigel, Jh" uniqKey="Beigel J">JH Beigel</name></author><author><name sortKey="Farrar, J" uniqKey="Farrar J">J Farrar</name></author><author><name sortKey="Han, Am" uniqKey="Han A">AM Han</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ge, Y" uniqKey="Ge Y">Y Ge</name></author><author><name sortKey="Wu, B" uniqKey="Wu B">B Wu</name></author><author><name sortKey="Qi, X" uniqKey="Qi X">X Qi</name></author><author><name sortKey="Zhao, K" uniqKey="Zhao K">K Zhao</name></author><author><name sortKey="Guo, X" uniqKey="Guo X">X Guo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhirnov, Op" uniqKey="Zhirnov O">OP Zhirnov</name></author><author><name sortKey="Ikizler, Mr" uniqKey="Ikizler M">MR Ikizler</name></author><author><name sortKey="Wright, Pf" uniqKey="Wright P">PF Wright</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Both, Gw" uniqKey="Both G">GW Both</name></author><author><name sortKey="Sleigh, Mj" uniqKey="Sleigh M">MJ Sleigh</name></author><author><name sortKey="Cox, Nj" uniqKey="Cox N">NJ Cox</name></author><author><name sortKey="Kendal, Ap" uniqKey="Kendal A">AP Kendal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gocnik, M" uniqKey="Gocnik M">M Gocník</name></author><author><name sortKey="Fislova, T" uniqKey="Fislova T">T Fislová</name></author><author><name sortKey="Mucha, V" uniqKey="Mucha V">V Mucha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ekiert, Dc" uniqKey="Ekiert D">DC Ekiert</name></author><author><name sortKey="Friesen, Rhe" uniqKey="Friesen R">RHE Friesen</name></author><author><name sortKey="Bhabha, G" uniqKey="Bhabha G">G Bhabha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corti, D" uniqKey="Corti D">D Corti</name></author><author><name sortKey="Voss, J" uniqKey="Voss J">J Voss</name></author><author><name sortKey="Gamblin, Sj" uniqKey="Gamblin S">SJ Gamblin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Okuno, Y" uniqKey="Okuno Y">Y Okuno</name></author><author><name sortKey="Isegawa, Y" uniqKey="Isegawa Y">Y Isegawa</name></author><author><name sortKey="Sasao, F" uniqKey="Sasao F">F Sasao</name></author><author><name sortKey="Ueda, S" uniqKey="Ueda S">S Ueda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gocnik, M" uniqKey="Gocnik M">M Gocník</name></author><author><name sortKey="Fislova, T" uniqKey="Fislova T">T Fislová</name></author><author><name sortKey="Sladkova, T" uniqKey="Sladkova T">T Sládková</name></author><author><name sortKey="Mucha, V" uniqKey="Mucha V">V Mucha</name></author><author><name sortKey="Kostolansk, F" uniqKey="Kostolansk F">F Kostolanský</name></author><author><name sortKey="Vare Kova, E" uniqKey="Vare Kova E">E Varečková</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pica, N" uniqKey="Pica N">N Pica</name></author><author><name sortKey="Hai, R" uniqKey="Hai R">R Hai</name></author><author><name sortKey="Krammer, F" uniqKey="Krammer F">F Krammer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steel, J" uniqKey="Steel J">J Steel</name></author><author><name sortKey="Lowen, Ac" uniqKey="Lowen A">AC Lowen</name></author><author><name sortKey="Wang, Tt" uniqKey="Wang T">TT Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eggink, D" uniqKey="Eggink D">D Eggink</name></author><author><name sortKey="Goff, Ph" uniqKey="Goff P">PH Goff</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Tt" uniqKey="Wang T">TT Wang</name></author><author><name sortKey="Tan, Gs" uniqKey="Tan G">GS Tan</name></author><author><name sortKey="Hai, R" uniqKey="Hai R">R Hai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bommakanti, G" uniqKey="Bommakanti G">G Bommakanti</name></author><author><name sortKey="Citron, Mp" uniqKey="Citron M">MP Citron</name></author><author><name sortKey="Hepler, Rw" uniqKey="Hepler R">RW Hepler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stanekova, Z" uniqKey="Stanekova Z">Z Stanekova</name></author><author><name sortKey="Mucha, V" uniqKey="Mucha V">V Mucha</name></author><author><name sortKey="Sladkova, T" uniqKey="Sladkova T">T Sládková</name></author><author><name sortKey="Blaskovi Ova, H" uniqKey="Blaskovi Ova H">H Blaškovičová</name></author><author><name sortKey="Kostolansk, F" uniqKey="Kostolansk F">F Kostolanský</name></author><author><name sortKey="Vare Kova, E" uniqKey="Vare Kova E">E Varečková</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krammer, F" uniqKey="Krammer F">F Krammer</name></author><author><name sortKey="Pica, N" uniqKey="Pica N">N Pica</name></author><author><name sortKey="Hai, R" uniqKey="Hai R">R Hai</name></author><author><name sortKey="Margine, I" uniqKey="Margine I">I Margine</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Margine, I" uniqKey="Margine I">I Margine</name></author><author><name sortKey="Krammer, F" uniqKey="Krammer F">F Krammer</name></author><author><name sortKey="Hai, R" uniqKey="Hai R">R Hai</name></author><author><name sortKey="Heaton, Ns" uniqKey="Heaton N">NS Heaton</name></author><author><name sortKey="Tan, Gs" uniqKey="Tan G">GS Tan</name></author><author><name sortKey="Andrews, Sa" uniqKey="Andrews S">SA Andrews</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Throsby, M" uniqKey="Throsby M">M Throsby</name></author><author><name sortKey="Van Den Brink, E" uniqKey="Van Den Brink E">E van den Brink</name></author><author><name sortKey="Jongeneelen, M" uniqKey="Jongeneelen M">M Jongeneelen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dreyfus, C" uniqKey="Dreyfus C">C Dreyfus</name></author><author><name sortKey="Laursen, Ns" uniqKey="Laursen N">NS Laursen</name></author><author><name sortKey="Kwaks, T" uniqKey="Kwaks T">T Kwaks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Js" uniqKey="Lee J">JS Lee</name></author><author><name sortKey="Chowdhury, My" uniqKey="Chowdhury M">MY Chowdhury</name></author><author><name sortKey="Moon, Hj" uniqKey="Moon H">HJ Moon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stanekova, Z" uniqKey="Stanekova Z">Z Stanekova</name></author><author><name sortKey="Adkins, I" uniqKey="Adkins I">I Adkins</name></author><author><name sortKey="Kosova, M" uniqKey="Kosova M">M Kosová</name></author><author><name sortKey="Janulikova, J" uniqKey="Janulikova J">J Janulíková</name></author><author><name sortKey="Sebo, P" uniqKey="Sebo P">P Šebo</name></author><author><name sortKey="Vare Kova, E" uniqKey="Vare Kova E">E Varečková</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dilillo, Dj" uniqKey="Dilillo D">DJ DiLillo</name></author><author><name sortKey="Tan, Gs" uniqKey="Tan G">GS Tan</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author><author><name sortKey="Ravetch, Jv" uniqKey="Ravetch J">JV Ravetch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wolff, Ja" uniqKey="Wolff J">JA Wolff</name></author><author><name sortKey="Malone, Rw" uniqKey="Malone R">RW Malone</name></author><author><name sortKey="Williams, P" uniqKey="Williams P">P Williams</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dhama, K" uniqKey="Dhama K">K Dhama</name></author><author><name sortKey="Mahendran, M" uniqKey="Mahendran M">M Mahendran</name></author><author><name sortKey="Gupta, Pk" uniqKey="Gupta P">PK Gupta</name></author><author><name sortKey="Rai, A" uniqKey="Rai A">A Rai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laddy, Dj" uniqKey="Laddy D">DJ Laddy</name></author><author><name sortKey="Yan, J" uniqKey="Yan J">J Yan</name></author><author><name sortKey="Corbitt, N" uniqKey="Corbitt N">N Corbitt</name></author><author><name sortKey="Kobasa, D" uniqKey="Kobasa D">D Kobasa</name></author><author><name sortKey="Kobinger, Gp" uniqKey="Kobinger G">GP Kobinger</name></author><author><name sortKey="Weiner, Db" uniqKey="Weiner D">DB Weiner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hillaire, Mlb" uniqKey="Hillaire M">MLB Hillaire</name></author><author><name sortKey="Osterhaus, Adme" uniqKey="Osterhaus A">ADME Osterhaus</name></author><author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dai, J" uniqKey="Dai J">J Dai</name></author><author><name sortKey="Pei, D" uniqKey="Pei D">D Pei</name></author><author><name sortKey="Wang, B" uniqKey="Wang B">B Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lambert, Lc" uniqKey="Lambert L">LC Lambert</name></author><author><name sortKey="Fauci, As" uniqKey="Fauci A">AS Fauci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wright, Pf" uniqKey="Wright P">PF Wright</name></author><author><name sortKey="Neumann, G" uniqKey="Neumann G">G Neumann</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y Kawaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buxton Bridges, C" uniqKey="Buxton Bridges C">C Buxton Bridges</name></author><author><name sortKey="Thompson, Ww" uniqKey="Thompson W">WW Thompson</name></author><author><name sortKey="Meltzer, Mi" uniqKey="Meltzer M">MI Meltzer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumar, P" uniqKey="Kumar P">P Kumar</name></author><author><name sortKey="Khanna, M" uniqKey="Khanna M">M Khanna</name></author><author><name sortKey="Kumar, B" uniqKey="Kumar B">B Kumar</name></author><author><name sortKey="Rajput, R" uniqKey="Rajput R">R Rajput</name></author><author><name sortKey="Banerjea, Ac" uniqKey="Banerjea A">AC Banerjea</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Khanna, Madhu" sort="Khanna, Madhu" uniqKey="Khanna M" first="Madhu" last="Khanna">Madhu Khanna</name></noRegion><name sortKey="Kumar, Binod" sort="Kumar, Binod" uniqKey="Kumar B" first="Binod" last="Kumar">Binod Kumar</name><name sortKey="Rajput, Roopali" sort="Rajput, Roopali" uniqKey="Rajput R" first="Roopali" last="Rajput">Roopali Rajput</name><name sortKey="Sharma, Sachin" sort="Sharma, Sachin" uniqKey="Sharma S" first="Sachin" last="Sharma">Sachin Sharma</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000686 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000686 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4055638
|texte= Protective Immunity Based on the Conserved Hemagglutinin Stalk Domain and Its Prospects for Universal Influenza Vaccine Development
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24982895" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |